This article was originally published here

Rev Endocr Metab Disord. 2022 April 1. doi: 10.1007/s11154-022-09721-0. Online ahead of print.


Acromegaly is a rare condition characterized by chronic hypersecretion of growth hormone (GH) and insulin-like growth factor (IGF-1) that causes somatic, metabolic, and systemic changes. The somatotropic axis acts physiologically by promoting gonadal function, but when GH is produced in excess, it has deleterious effects on many aspects of male sexuality. It has indeed been widely demonstrated that acromegaly induces hypogonadism by different mechanisms, both by direct mass effect on the gonadotropic cells and by increased plasma levels of prolactin. Moreover, hypogonadism is also one of the factors linking acromegaly to erectile dysfunction (ED), but also the metabolic complications of acromegaly and, probably, GH itself contribute to the genesis of this disorder. . There are few data in the literature on the impact of the disease on fertility and testicular volume. Finally, knowledge of the role of GH hypersecretion on the occurrence of prostatic pathologies such as benign prostatic hypertrophy and prostatic cancer appears to be of fundamental clinical importance in the long-term management of these patients.

PMID:35364803 | DO I:10.1007/s11154-022-09721-0