A new lab study involving mice has found a link between a commonly used erectile dysfunction drug and abdominal aortic aneurysms. This new information has prompted scientists to say more research is needed to determine if the drug can have the same effect on people.

The drug in question, sildenafil, is commonly used to treat pulmonary hypertension and is widely prescribed to treat erectile dysfunction. The drug works by blocking enzymes that regulate the contraction of vascular smooth muscle cells.

An abdominal aortic aneurysm is a weakening or bulging of the lower part of the aorta which carries blood from the heart to the abdomen, pelvis and legs. If a dissection occurs (a tear in the inner layer of the large blood vessel), it can lead to further damage to the arterial wall.

A ruptured abdominal aortic aneurysm is a medical emergency that only about 20% of patients survive. These types of aneurysms occur more frequently in men with risk factors, including a family history of the disease, high cholesterol, high blood pressure, smoking, emphysema, and obesity.

The study published in the Journal of the American Heart Association explored the impact of abdominal aortic aneurysm progression when sildenafil was ingested in mice.

Small abdominal aortic aneurysms were surgically induced in mice and the size of their aortas was monitored. Aortic aneurysms formed seven days after surgery, and the mice were then randomized into two groups for four weeks.

Half of the mice received sildenafil diluted in water daily for four weeks, and the second group of mice received water containing no sildenafil.

After four weeks, mice receiving sildenafil had larger abdominal aortic aneurysms, about 37% larger on average. They also had approximately 50% degradation or weakening in addition to the elastic fibers in the abdominal aortic aneurysm.

Study author Chen Yan Ph.D. said, “Our study suggests that sildenafil worsened the progression of abdominal aortic aneurysms, likely by disrupting the ability of smooth muscle cells to contract and function properly. These results may suggest caution in prescribing PDE5 inhibitors such as sildenafil for patients with existing aortic aneurysmal lesions. Clinical studies and other types of animal models of abdominal aortic aneurysm may be warranted to investigate this further.

A growing concern

Men’s health is a growing concern for many as they age. Knowing which drugs can be dangerous if you have pre-existing conditions is critical, so studies like this are essential to help doctors prescribe the right drugs for their clients.

Testosterone Resue is a natural supplement that can help promote testosterone production in men. It contains a unique formula of ingredients that have been clinically proven to boost libido and sexual desire.

As men’s testosterone levels decline with age, it is essential to support and promote healthy testosterone levels. Low levels can impact your sex life, energy, and overall quality of life.