Newswise – Rockville, Maryland (September 29, 2021) –The results of a new study indicate that erectile dysfunction and inflammation could be prevented by blocking the effect of endothelin-1, which is a potent vasoconstrictor and blood flow regulator peptide. A research team from Aarhus University in Denmark will present their findings virtually October 4-7 in Seventeenth International Endothelin Conference (ET-17), hosted and organized by the American Society of Physiology.

There is a strong and established link between heart disease and erectile dysfunction, which is the inability to get and maintain an erection for sex. About half of all men with erectile dysfunction are at “high risk for cardiovascular disease,” according to study author Rafael Fais, PhD, of National Jewish Health in Denver.

Endothelin-1, also called downstream signaling pathways, is released from the inner cell layer of blood vessels. It is closely associated with erectile dysfunction and inflammation because it can increase blood pressure. In this study, conducted using a mouse model, Fais blocked endothelin-1 using an endothelial type A and B receptor antagonist called bosentan. Bosentan was injected directly into the cavernous tissue of the penis, confirming the role of endothelin-1 in erectile dysfunction.

The results suggest that endothelin-1 may play an important role in reducing erectile dysfunction and inflammation. Hopefully this study will lead to new drugs to treat erectile dysfunction and heart problems. Another goal is to increase the quality of a couple’s life by improving their sexual relationship.

NOTICE TO JOURNALISTS: To schedule an interview with a member of the research team and / or request the summary, “Small calcium-activated potassium channel openers can recover impaired endothelial and erectile function induced by activation of endothelin-1-NLRP3, “please contact APS Media Relations or call 301.634.7314. Discover other research highlights in the APS press room.

Physiology is a broad area of ​​scientific research that focuses on the function of molecules, cells, tissues, and organs in health and disease. The American Physiological Society connects a global multidisciplinary community of more than 10,000 biomedical scientists and educators as part of its mission to advance scientific discovery, understand life, and improve health. The Society fosters collaboration and highlights scientific discoveries through its 16 scholarly journals and programs that support researchers and educators in their work.


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