Gender Med Rev. 2021 November 20: S2050-0521 (21) 00085-8. doi: 10.1016 / j.sxmr.2021.11.001. Online ahead of print.


INTRODUCTION: Long-term complications from COVID-19, the disease caused by SARS-CoV-2, involve many organ systems, dramatically worsening quality of life and ultimately contributing to impaired physical functioning. Despite the presence of well-identified pathogenic mechanisms, the effect of “Long COVID” on sexual health has only been marginally addressed.

OBJECTIVES: To provide current literature coverage on the long term COVID, its epidemiology, pathophysiology, and relevance to erectile function.

METHODS: Comprehensive review of the literature concerning the epidemiology and pathophysiology of long-term COVID, and its relevance for erectile function.

RESULTS: Symptoms of long-lasting COVID are widespread and involve almost every system in the human body, with a plethora of clinical manifestations ranging from minor nuisances to life-threatening conditions. “Brain fog” and fatigue are the most common complaints, although other neuropsychiatric complications, including sensory dysfunction, anxiety, depression, and cerebrovascular events, have also been reported. The respiratory and cardiovascular systems are also affected, with dyspnea, pulmonary fibrosis, endothelial dysfunction and myocarditis occurring in some long-haul COVIDs. A subset of patients may develop endocrine manifestations, including the development of diabetes, thyroid dysfunction, and hypogonadism. Overall, the long-term COVID presents many complications that can impair erectile function through multiple pathogenetic mechanisms, and which may require tailor-made treatment: (i) careful investigation and management by the expert in Sexual medicine are therefore essential, (ii) and future research on this subject is guaranteed.

CONCLUSION: In long-haul COVID-19, several complications can negatively affect erectile function which, in future tailored studies, could be used as a biomarker of the severity of the long-term COVID disease and its follow-up. Sansone A, Mollaioli D, Limoncin E et al. The Sexual Long COVID (SLC): Erectile dysfunction as a biomarker of systemic complications for long-haul COVID-19. Gender Med Rev 2021; XX: XXX-XXX.

PMID: 34933829 | DOI: 10.1016 / j.sxmr.2021.11.001